| Matt Damon | Mark Whitacre |
| Melanie Lynskey | Ginger Whitacre |
| Frank Welker | Mr. Whitacre |
| Scott Bakula | Brian Shepard, FBI-agent |
| Joel McHale | Robert Herndon, FBI-agent |
| Thomas F. Wilson | Mark Cheviron |
| Patton Oswalt | Ed Herbst |
| Edward Jemison | Kirk Schmidt |
| Scott Adsit | Sid Hulse |
| Rusty Schwimmer | Elizabeth |
| Arden Myrin | Sarah Scott |
| Elena Eustache | den schweiziska sekreteraren |
| Candy Clark | Mrs. Whitacre |
| Tony Hale | |
| Mike O'Malley | |